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• This page intentionally left blank. • Pharmaceutical Calculations13th Edition • PharmaceuticalCalculations13th Edition Howard C. Ansel, PhDProfessor and Dean EmeritusCollege of PharmacyUniversity of GeorgiaAthens, Georgia • Acquisitions Editor: John GoucherManaging Editor: Matt HauberDirector of Nursing Production: Helen EwanSenior Managing Editor/Production: Erika KorsSenior Production Editor: Marian BellusDesigner: Holly McLaughlinManufacturing Coordinator: Margie OrzechProduction Services/Compositor: Maryland Composition/ASI 13th Edition Copyright 2010 Wolters Kluwer Health Lippincott Williams & Wilkins.Copyright 2006, 2001, 1996, 1991, 1986 by Lippincott Williams & Wilkins. All rights reserved. Thisbook is protected by copyright.

No part of this book may be reproduced or transmitted in any form or byany means, including as photocopies or scanned-in or other electronic copies, or utilized by any informationstorage and retrieval system without written permission from the copyright owner, except for brief quotationsembodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part oftheir official duties as U.S. Government employees are not covered by the above-mentioned copyright. Torequest permission, please contact Lippincott Williams & Wilkins at 530 Walnut Street, Philadelphia PA19106, via email at permissions @ lww.com or via website at lww.com (products and services). This textbook is intended to provide the underpinnings of the methods used in pharmaceutical calculations. Thedrugs, drug products, formulas, equations, uses, and doses are included in this textbook for the sole purpose ofproviding examples in the types of calculations described.

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The information is not intended for use in any practiceor clinical application, nor should it be considered or construed as specific for any individual patient nor as asubstitute for current drug package inserts. The author, editors, and publisher make no warranty, express orimplied, with regard to the contents and use of this publication and are not responsible, as a matter of productliability, negligence, or otherwise, for any injury resulting from any material contained herein. 9 8 7 6 5 4 3 2 1 Printed in China First Edition, 1945 Library of Congress Cataloging-in-Publication Data Ansel, Howard C., 1933-Pharmaceutical calculations / Howard C.

Ansel.13th ed. P.; cm.Includes bibliographical references and index.ISBN 978-1-58255-837-01. Pharmaceutical arithmetic. Title.[DNLM: 1.

Drug Dosage Calculations. Dosage Forms. Drug Compoundingmethods. Prescriptions, Drug. Weights and Measures.

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QV 748 A618p 2010]RS57.S.1401513dc672 Care has been taken to confirm the accuracy of the information presented and to describe generallyaccepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions orfor any consequences from application of the information in this book and make no warranty, expressed orimplied, with respect to the currency, completeness, or accuracy of the contents of the publication.Application of this information in a particular situation remains the professional responsibility of thepractitioner; the clinical treatments described and recommended may not be considered absolute anduniversal recommendations. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage setforth in this text are in accordance with the current recommendations and practice at the time of publication.However, in view of ongoing research, changes in government regulations, and the constant flow ofinformation relating to drug therapy and drug reactions, the reader is urged to check the package insert foreach drug for any change in indications and dosage and for added warnings and precautions. This isparticularly important when the recommended agent is a new or frequently employed drug. Some drugs and medical devices presented in this publication have Food and Drug Administration (FDA)clearance for limited use in restricted research settings. It is the responsibility of the health care provider toascertain the FDA status of each drug or device planned for use in his or her clinical practice.